Optimizing Voltage Parameter of Deep Brain Stimulation for Parkinsonian Patients by Modeling

Deep Brain Stimulation or DBS is the second solution for Parkinson's Disease. Its three parameters are: frequency, pulse width and voltage. They must be optimized to achieve successful treatment. Nowadays it is done clinically by neurologists and there is not certain numerical method to detect them. The aim of this research is to introduce simulation and modeling of Parkinson's Disease treatment as a computational procedure to select optimum voltage. We recorded finger tremor signals of some Parkinsonian patients under DBS treatment at constant frequency and pulse width but variable voltages; then, we adapted a new model to fit these data. The optimum voltages obtained by data fitting results were the same as neurologists’ commented voltages, which means modeling can be used as an engineering method to select optimum stimulation voltages. Keywords—modeling, Deep Brain Stimulation, Parkinson's disease, tremor.